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Neurology is particularly high stakes: the EVOKE and EVOKE+ Phase 3 trials of semaglutide in early Alzheimers disease, due in 202526, will be the first large-scale cognitive readouts

doi: 10.1146/annurev-immunol-031210-101312 41 CalvanoSEXiaoWRichardsDRFelcianoRMBakerHVChoRJet al

Diabetes 58(4):975983 Nystrm T, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahrn B, Sjholm A (2004) Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease

Because this was not a randomized trial, the study compared participants already taking GLP-1 RAs with matched controls not using these drugs