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In patients on single morning doses of intermediate-acting glucocorticoids and with no prior insulin treatment, NPH insulin or a biphasic regimen before breakfast may be started, while maintaining non-insulin antidiabetic drugs (Appendix A, Table 7 of Supplementary material).32 Insulin reductions proportional to corticosteroid dose reduction are generally recommended

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Fast liquid chromatography (FPLC) analysis of nephrotic serum revealed a decreased 150 kDA IGFBP ternary complex due to reduced intact IGFBP-3, whereas IGFBP-3 low molecular weight fragments were markedly increased, suggesting increased proteolytic degradation of IGFBP-3