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By engaging GLP-1 receptors distributed throughout various organ systemsincluding the pancreas, gastrointestinal tract, brain, heart, and kidneysthese agents influence multiple physiological processes

Most randomized controlled trials and observational and clinical studies have demonstrated that DPP-4 inhibitors are safe in regard to bone and may decrease the risk of fractures in patients with T2DM [37]

Symptoms include: Rapid breathing Extreme fatigue Loss of appetite Irregular heartbeat Your doctor will likely want to perform regular blood work to check your bicarbonate levels if you are taking both medications