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2011, titled Tobacco addiction and psychological co-morbidities. Physically, nicotine affects the brains reward system, releasing neurotransmitters like dopamine, which leads to cravings and withdrawal symptoms when tobacco use is reduced or stopped

A Cochrane review found that successful quitters may gain an additional average of about 2 to 5 kg over the first five years, and up to about 7 kg by eight years in some estimates

Intense distress or worry Sense of detachment Heart palpitations Chest pain Trouble breathing Sweating Chills Trembling Numbness or tingling Nausea or abdominal pain Faintness or dizziness Unlike anxiety, panic attacks can be expected or unexpected, making them even more overwhelming