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Examples of psychoactive substances include caffeine, alcohol, cocaine, LSD, nicotine, cannabis, and dextromethorphan

This actually gives a glimmer of hope to someone who has been struggling to quit for a long time, but can't

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So when Horowitz returned home to Queens, New York after a day of shepherding Moore around the city, it caused a stir when he produced from his weather-beaten briefcase a signed promotional headshot of Moore, himself looking rather weather-beaten, with crow's feet around his eyes, a rogue's smile on his mouth, an unbuttoned white collar on his neck and rugged furrows in his Hollywood-tanned brow