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Risk categories were defined using the CRAFFT 2.1 screening tool and operationalized based on both SU behaviors reported in the past 12 months and CRAFFT scores, following the developers cut-off criteria

63 Finally, an open-label randomized study of 6 weeks, compared gabapentin (n = 17) and bupropion (n = 19) for smoking reduction, and alleviation of withdrawal syndrome severity

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Across the 11 newer EU states in Central and Southeast Europe, consumption of C&C cigarettes dropped from 12.3bn in 2018 to 10.7bn in 2019