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mSOD1 Tregs co-cultured with mSOD1 adult microglia repressed cytotoxic microglial factors such as NOX2 and iNOS through an IL-4-mediated mechanism

This binding triggers the natural production and release of endogenous growth hormone (GH), rather than supplying exogenous GH directly

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What this tells us is that we have enough information to think about doing longer term prospective controlled studies to see if it is a real finding and, if it is, whether or not we should be specifically targeting patients with rosacea, regardless of their skin type, because they have a higher risk of developing melanoma. Notably, the study does not include any data about skin type or UV exposure, which is a factor in both melanoma development, rosacea exacerbation and possibly rosacea development