what are the physical effects of tobacco File:Adverse smoking.svg Smoking Tobacco Health Effects -

The pharmacologic effect of nicotine at BBB is partly due to stimulation of nAchRs in brain endothelial cells that express -3, -5, -7, -2, and -5 of its subtypes (Moccia et al., 2004)

The GM can boost the immune system (Thomas et al., Reference Thomas, Izard, Walsh, Batich, Chongsathidkiet, Clarke, Sela, Muller, Mullin and Albert2017), control digestion (Passos and Moraes-Filho, Reference Passos and Moraes-Filho2017), and lessen the chance of developing inflammatory diseases like cancer and diabetes (Halfvarson et al., Reference Halfvarson, Brislawn, Lamendella, Vzquez-Baeza, Walters, Bramer, Damato, Bonfiglio, McDonald and Gonzalez2017

It can increase the adrenaline circulating in our bodies and activate the sympathetic nervous system (our fight or flight response), raising blood pressure, speeding up the heart rate, and causing the arteries the vessels that carry blood to narrow

Inside the brain, nicotine primarily affects the nicotinic acetylcholine receptors (nAChRs), which are responsible for controlling neurotransmitters like acetylcholine, dopamine, and serotonin