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Statistical analysis Cox proportional hazards models were used to examine the associations between cigar status and mortality outcomes based on underlying causes of death from the 10th revision of International Statistical Classification of Diseases and Related Health Problems (ICD-10) [21], reported as hazard ratios (HRs, with 95% confidence intervals, CI) with never smokers as the referent group

Drew University Accelerating Excellence in Translational Science (AXIS) (grant U54MD007598) for help with editing the manuscript

These findings have bearing on the use of reduced-nicotine cigarettes to facilitate smoking cessation and on policy regarding regulation of nicotine content in cigarettes

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