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N-acetylcysteine: Free radicals are known to trigger sickling of red blood cells

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(vi) signal transduction from the environment to cellular transcription machinery ( GSH AS MAIN REGULATOR OF CELLULAR REDOX STATUS AND REDOX SIGNAL TRANSDUCTION The glutathione redox couple GSH/GSSG has a great importance in the cells and together with other redox-active couples, including NADPH/NADP + , Trx-SH/Trx-SS regulates and maintains the appropriate cellular redox status

Kotogn, T