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Participants will be classified as abstinent if they respond no to both of the following questions: (i) have you smoked any cigarettes (even a puff) in the last 7 days? and (ii) Have you used any tobacco product (i.e., chew, snuff, pipe, cigar, etc.) in the last 7 days? Self-report will be biochemically confirmed with expired CO at each in-person visit and urinary anabasine at week 13

This is the first demonstration that these new chemicals formed in e-liquids can damage and kill lung cells and probably do this by damaging their metabolism