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Concurrently, the expression and activity of electron transport chain(ETC) complexes were significantly upregulated, suggesting that acute CS exposure may induce a metabolic adaptation primarily driven by oxidative stress rather than by inflammation

But, as Stein notes, only by doing prospective longitudinal studies can we begin to get at the causal chain here. Stein and colleagues recommend that future studies look at mood disorders as a factor in the relationship between marijuana use and sleep