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Funding This work was funded by the Departamento de Cincia e Tecnologia (DECIT, Ministrio da Sade, Brazil), Fundo Nacional de Desenvolvimento Cientfico e Tecnolgico (FNDCT, Ministrio da Cincia e Tecnologia, Brazil), Fundao Financiadora de Estudos e Projetos (FINEP, Ministrio da Cincia e Tecnologia, Brazil), Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq, Brazil), and Fundao de Amparo Pesquisa do Estado de Minas Gerais (FAPEMIG-MG)