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56 CORT can activate TRPV1/TRPA1 receptors through oxidative stress or direct receptor interactions, trigger calcitonin gene-related peptide (CGRP) release, promote histamine secretion, impair gastric mucosal barrier function, increase gastric acid permeability, and enhance sensitivity to reflux stimuli

Safety Considerations There are currently no published studies specifically examining the combination of Dsip and Tirzepatide in humans