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Bottom Line Cigarettes continue to fall out of favor with Americans, as only about one in eight U.S
It is clear that companies are finding loopholes at the expense of their customers
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Cigarette smoke contains a large number of toxic substances, including a large number of oxygen metabolite-derived or reactive oxygen species (ROS), which can directly disrupt this physical barrier, resulting in increased permeability of respiratory epithelial cells and hindering clearance of mucus cilia [28]
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