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The shift was backed, however, by major tobacco companies and the leading e-cigarette maker Juul Labs

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The third wave began when powerful synthetic opioids such as fentanyl started appearing in the supply around 2015

Selling Smoke: Tobacco Advertising and Anti-Smoking Campaigns Item Marlboro Country - Light Title Marlboro Country - Light Description A cowboy with a rope lights a cigarette Creator Marlboro Publisher Philip Morris Date 1968 Source Image from the William Van Duyn Tobacco Advertisement Collection (Ms Coll 20), Medical Historical Library, Harvey Cushing/John Hay Whitney Medical Library, Yale University