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Introduction Platinum (Pt) drugs, such as cisplatin (CP), oxaliplatin (OXA), and carboplatin, are commonly used in the treatment of colorectal cancer ( 2 ), singlet oxygen ( 1 O 2 ), hydrogen peroxide (H 2 O 2 ), hydroxyl radical (OH), and so on, would induce oxidative damage to biomolecules (e.g., proteins, lipids, and DNA) and, thus, lead to severe cellular damage ( 2 ( 2 ( To solve the challenge, numerous researchers devote to exploring the mechanism of PIPN, which are principally implicated in transporter overexpression ( Currently, some antioxidant agents have been utilized to treat PIPN in clinical trials and animal studies by relieving the Pt-induced ROS upregulation

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