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The Phase 3 study evaluated orforglipron, an investigational, once-daily oral small molecule glucagon-like peptide-1 (GLP-1) receptor agonist, for weight maintenance over 52 weeks after initial treatment for 72 weeks with the highest tolerated doses of Wegovy (semaglutide) or Zepbound (tirzepatide), in participants from SURMOUNT-5 who were offered the opportunity to be re-randomized to receive orforglipron or placebo

Sizar O, et al

This size difference is somewhat noticeable when the birds are seen in migration and becomes exaggerated on the breeding grounds because the males put on extra weight

"Glucagon-like Peptide-1 Receptor Agonists and Suicidal Ideation: Analysis of Real-World Data Collected in the European Pharmacovigilance Database." Pharmaceuticals, vol