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Several different smoking-related phenotypes have been studied, including smoking initiation (SmkInit) (Saunders et al., Reference Saunders, Wang, Chen, Jang, Liu and Wang2022), cigarettes per day (CPD) (Saunders et al., Reference Saunders, Wang, Chen, Jang, Liu and Wang2022), the Fagerstrm Test for Nicotine Dependence (FTND) (Quach et al., Reference Quach, Bray, Gaddis, Liu, Palviainen, Minica and Hancock2020), problematic tobacco use (PTU) (Hatoum et al., Reference Hatoum, Johnson, Colbert, Polimanti, Zhou, Walters and Agrawal2022), tobacco use disorder defined by codes from the International Classification of Diseases (ICD-based tobacco use disorder [ICD-TUD]) (Toikumo et al., Reference Toikumo, Jennings, Pham, Lee, Mallard and Bianchi2024, and nicotine dependence (Loukola et al., Reference Loukola, Wedenoja, Keskitalo-Vuokko, Broms, Korhonen, Ripatti and Kaprio2014) defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) (Table 1)
