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Eligible studies included observational designs and randomized trials involving human participants that reported the prevalence or incidence of MI or stroke

Among smokers and ex-smokers, the age at which smoking was started (and stopped in the case of ex-smokers) and the number of cigarettes consumed a day were recorded

In May 2015, the official Kyodo news agency reported on a health ministry research group which said that four of the nine e-cigarette brands that can currently be legally sold in Japan (because they do not dispense or contain nicotine) produce vapor with high levels of formaldehyde, a known carcinogen

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