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Additionally, these are available in 3mg, 6mg, and 12mg nicotine bases, as well as a nicotine-free version for those who prefer the juicy taste by itself

These may include: urge to smoke, depressed mood, trouble sleeping, irritability, frustration, anger, feeling anxious, difficulty concentrating, restlessness, decreased heart rate, increased appetite, and weight gain

To further confirm this chain of causal inference, we implemented a modified Mendelian randomisation (MR) analysis to investigate potential causal effects by introducing non-pleiotropic polygenic risk scores (PRS) as instrument variables, i.e., the valid-PRS (see Methods for more details) 35,36

is $15.07 per hour