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Bioavailability: Subcutaneous delivery provides near-complete absorption into systemic circulation, bypassing the digestive system where oral glutathione is largely broken down into amino acids

However, since the differences in total GSH conjugation activity catalyzed by these allelic variants are not higher than 30 %, the differences in inactivation of reactive intermediates by hGSTP1-1 are not likely to be a major factor in determining interindividual difference in susceptibility to adverse drug reactions induced by the drugs studied [34]

Nanodelivery systems are required to optimise the targeting efficacy