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379 In PGC-1 knockout mouse models, DA neurons exhibit increased sensitivity to the neurotoxin MPTP, potentially due to the lack of PGC-1-mediated induction of antioxidant responses

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The major ferroptosis-related pathways influenced by polysaccharides are the SLC7A11/GSH/GPX4 pathway, Keap1/Nrf2/HO-1 pathway, NCOA4-mediated ferritinophagy pathway, ACSL4-mediated lipid peroxidation pathway, and their upstream signal such as PI3K/Akt, Wnt/-catenin, p53, and the AMPK/BECN1 autophagy pathway

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