Classic EDS is inherited in an autosomal dominant manner and is caused by mutations in COL5A1 or COL5A2, which encode the alpha-1 and alpha-2 chains, respectively, of collagen type V.1 The disease is characterized by skin hyperextensibility, joint hypermobility and associated complications (luxations, pain, early osteoarthritis), and other clinical characteristics that are reviewed in a recent international consensus paper.1 Dermatologic manifestations of classic EDS include skin hyperextensibility and abnormal scarring, which results the formation of atrophic scars with a cigarette-paper-like appearance
Ghislaine was one of the first people in New York to walk around with a cellular phone, and she would very ostentatiously put it on the table at lunch, says Christopher Mason, the British writer and TV host
Ten of these patients showed the typical cEDS scars and 5 of them also had an affected family member fulfilling the criteria, thus prompting molecular analysis
However, generally, a person will have a runny or stuffy nose
