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Interested in this topic, you can read more in several articles: fat loss vs weight loss, the effects of medically induced weight loss on skeletal muscle, changes in fat-free mass during significant weight loss: a systematic review, and fat-free and skeletal muscle loss with GLP-1 treatments

DOI: 10.1111/bjd.13598 MC1R Selectivity and Receptor Pharmacology Comparative receptor binding studies have confirmed MT-1s preferential activity at MC1R versus the broader receptor profile of MT-2, establishing it as the reference compound for isolated MC1R pathway research

Categorical variables were expressed as frequencies and percentages

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