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Experienced smokers, who inhale deeply and hold the smoke in the lungs virtually all of the cannabinoids present in the mainstream smoke enter the bloodstream, which means very little of the smoke that gets exhaled by experienced users contains THC

Effects can linger for up to 4 hours

If you feel too high, stay calm, hydrate, have a snack, and rest in a quiet room the effects are temporary and will pass

A clinically reviewed interaction guide warns that combining cannabis with sertraline can increase extreme drowsiness, dizziness, and confusion, and that cannabis can sometimes worsen the anxiety or depression sertraline treats