In the event of a stroke, the depletion of adenosine triphosphate (ATP) triggers the ischemic cascade, which ultimately leads to the accumulation of calcium within the cells, the failure of the ion pump, and the glutamate-induced cell excitotoxicity (17)
It has been reported that hypnotics such as diazepam and zolpidem enhance GABAergic inhibitory signaling by prolonging the decay time constant of GABA A receptors in various brain region including thalamus, hippocampus, and neocortex [33,34,57-59]
Gastrointestinal effects nausea, vomiting, diarrhea, and constipation are the most common and can be amplified when two appetite-suppressing compounds are used together
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