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In spite of 40 years of research the exact function of this protein is more complex than ever, but it has been found that these intracellular dimeric proteins, play a major role in the intracellular transport of endogenous compounds, metabolizes various electrophilic xenobiotics, ligand transport and thus protects cells against toxic effects [31], [87], [85]

We expect this approach to be useful for the development of peptide therapeutics and we are currently evaluating its generalization to other peptide sequences and protein targets of therapeutic interest

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First, the stepwise increase in weight loss as additional receptor mechanisms are added (GLP-1 only to GLP-1+GIP to GLP-1+GIP+glucagon) is consistent with the additive-mechanism hypothesis that underpinned the retatrutide program