Albeit the cEDS-specific triad, i.e., widened, atrophic scars (92% of patients and ~ 95% of probands), marked skin hyperextensibility (80% of patients and ~ 82% of probands), and gJHM (BS 5, ~ 59% of patients and ~ 66% of probands), is highly predictive for molecular confirmation of the diagnosis, this combination was observed only in ~ 49% of patients and in ~ 55% of probands
King size box: Standard king size boxes usually measure around 85mm 55mm 22mm, fitting 20 regular cigarettes comfortably, preventing damage, maintaining freshness, and providing enough space for branding and regulatory labeling
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At that time in history, smoking was seen as a mere habit to break, and cigarettes were even marketed as digestion aides