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Torin1 and NAC, which alleviated nicotine-induced mitophagic flux impairment and mitochondrial dynamics disorder, also prevented apoptosis in NRVMs as demonstrated by decreased expression of cleaved PARP and cleaved caspase 3 compared with nicotine injury (Figures 7AF) and reduced number of TUNEL-positive cells compared with the nicotine group (Figures 7G,H)

Smoking during pregnancy has been associated with miscarriage, premature births and complications during birth

[30] In September, RJR agreed to pay $10 million to San Francisco and the other California cities and counties who intervened in the Mangini litigation

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