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Since then, several studies have proven the critical role of nAChRs activation in modulating neuro-immune pathways, and nicotine has been investigated as an effective therapeutic in neurodegeneration and neuroinflammatory diseases [193, 194]

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Early studies have shown a correlation between the use of e-cigarettes and lung injury [12, 106], with e-cigarette users showing increased respiratory symptoms, an elevated risk of developing airway disease and a decline in lung function [107]

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