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Because of high energy requirements, neurons are especially vulnerable to mitochondrial dysfunction, as seen in various neurodegenerative disorders such as Alzheimers disease (AD), Parkinsons disease (PD), Huntingtons disease (HD), amyotrophic lateral sclerosis (ALS) and Friedreichs ataxia (Chaturvedi and Flint Beal 2013

It can sometimes feel unfair, with those who don't smoke - or vape - feeling discriminated against

Thus, agonists of the CB-receptors may cause increased cravings for nicotine, which may explain the common desire to smoke cigarettes immediately after cannabis, or the heightened subjective level of satisfaction derived from smoking the two together

For instance, someone who takes a 3-second drag at 3% nicotine might have a higher intake than someone who takes a 3-second drag at 0.5% nicotine