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The symptoms of meningococcal disease may include a sudden onset of fever, severe headache, weakness, drowsiness, confusion or coma, sore legs or sore joints, nausea and vomiting, a dislike of bright lights, a stiff neck and a rash of red-purple spots

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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and it's potential costs to the body was born