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Clear and strong localization of p53-pS15 and FOXO4 was observed in the nuclei of keloid fibroblasts

Studies with specific inhibitors of p44/42 and JNK support that the TNF-mediated increase in lipolysis is largely attributed to a reduction in perilipin levels in adipocytes (104, 105), and lower levels of perilipin have been found in adipose tissues from obese subjects (135)

10.1016/j.chembiol.2020.02.005 69 LiuS.-J.ZhaoQ.PengC.MaoQ.WuF.ZhangF

This concern appears to stem from glutathione's skin-brightening mechanism, which works by inhibiting melanin production through tyrosinase modulation a temporary, dose-dependent, and generally reversible effect, not an autoimmune depigmentation process like vitiligo