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The FDA has been focusing on lowering nicotine levels since the 1990s as it attempts to crack down on cigarette sales to minors, but the Supreme Court had found the FDA wasn't permitted to do so at the time

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It has been studied as a treatment for multiple disease states and health conditions, including bipolar mania, Huntingtons disease, inflammation, insomnia, multiple sclerosis, nausea, social anxiety disorder, schizophrenia, and seizures

Brands had long used this lack of knowledge to position certain cigarettes as healthier, but as evidence began mounting, many of these shifted toward competing aggressively on filtration