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Cigarette smoke induces COPD-related airway remodeling phenotypes, including airway epithelial hyperplasia, myocyte hyperplasia, squamous metaplasia, EMT, ciliary alterations, loss of secretory cells that produce Scgb1a1, and reduced integrity of the apical junction barrier that controls airway epithelial permeability

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It will, of course, be difficult to measure how many smokers quit because of the addition of warning labels rather than anything else in the battery of anti-smoking efforts and regulations

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