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As a systematic review by the Cochrane Library noted: The small number of trials, low event rates and wide confidence intervals around the estimates mean that our confidence in the result is rated low. For example, there were weaknesses in the randomized trials

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If you have a lot of printing requirements, such as printing intricate designs or using many colors, we suggest using cardboard

The data presented above for the split-tipping cigarettes suggested that no significant impact on volatile yields would be expected for the 7-mg ISO tar cigarettes designed for this study