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Subgroup analyses by age, sex, nicotine dependence, and mental illness showed greater effectiveness of VNP compared to NRT in achieving smoking cessation

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Nicotinic cholinergic receptors Nicotinic cholinergic receptors (nAChRs), target of nicotine, belong to ionotropic class of receptors, which act by directly regulating the opening of a cation channel in the neuronal membrane [6, 7, 8]