The possible roles of TNP1, revealed by in vitro investigations, include relaxation of the DNA in nucleosome core particles, decreasing the melting temperature of DNA, and stimulation of the DNA-relaxing activity of topoisomerase I [73, 75, 76, 77, 78]
88 , 89 , 93-95 Harmful reactive oxygen compounds (such as hydrogen peroxide), and a range of carbonyl compounds (including toxic aldehydes such as acrolein, 89 formaldehyde, acetaldehyde and butyraldehyde), 93 , 96 pyrene, benzo[a]pyrene and other carcinogenic polycyclic aromatic hydrocarbons 89 , 94 have been found in emissions from heated tobacco products
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Plan B should be used as soon as possible after unprotected sex