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Abbreviations 7 nAChR 7-homomeric nicotinic acetylcholine receptor BBB blood brain barrier BSA bovine serum albumin Cig cigarette-exposed mice DEG differentially expressed genes DI discrimination index EC0% nicotine-free e-cigarette exposed mice EC1.8% nicotine-containing e-cigarette exposed mice e-cigarettes, vaping electronic cigarettes e-liquid e-cigarette refill liquid EPM elevated plus maze FITC fluorescein isocyanate Glut1 solute carrier family 2 (facilitated glucose transporter), member 1 (encoded by Slc2a1 ) Iba1 ionized calcium binding adaptor molecule 1 (encoded by Aif1 ) icv intracerebroventricular LEL Lycopersicon Esculentum lectin NaF sodium fluorescein NORT novel object recognition test PG propylene glycol qPCR quantitative polymerase chain reaction ROI region of interest SAT spontaneous alternation task SE standard error of the mean smoking, cigarettes combustible tobacco cigarettes TJ tight junction TMR tetramethylrhodamine tpm total particulate matter VG vegetable glycerin Footnotes Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication

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