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The days of Clint Eastwood, John Wayne and Humphrey Bogart exuding effortless cool with a cigarette handing from their lips are a thing of the past, not to mention Philip Morris paying $350,000 for the privilege of having its Lark brand displayed prominently in James Bond movie Licence to Kill
TS induced vascular endothelial dysfunction has been shown to be mediated by the deleterious properties of TS, primarily those relating to reactive oxygen species (ROS) content (Naik et al., 2014), nicotine, and oxidative stress derived inflammation, in a dose-dependent manner (Gill et al., 1989
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