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[48] Naltrexone may also initially produce opioid withdrawal-like symptoms in a small subset of people not dependent on opioids: [58] The side-effect profile [of naltrexone], at least on the recommended dose of 50 mg per day, is generally benign, although 5 to 10 percent of detoxified opioid addicts experience immediate, intolerable levels of withdrawal-like effects including agitation, anxiety, insomnia, light-headedness, sweating, dysphoria, and nausea

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