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Future studies are needed to better understand the clinical significance for the magnitude of the effect by PG and VG, varying ratios of the two and longer duration of use as well as effects of flavors. Journal reference: Effects of Electronic Cigarette Constituents on the Human Lung: A Pilot Clinical Trial Min-Ae Song, Sarah A

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Specifically, cigarette smoking has been shown to independently raise total and free testosterone levels, even after controlling for various external factors