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Subgroup analysis by study design showed that the pooled OR of cohort studies was unadjusted 1.18 (95% CI: 0.961.44, I 2 =77%, p=0.11) and adjusted 1.18 (0.96-1.44, I 2 =77%, p=0.11), while that of case-control studies was unadjusted 1.12 (95% CI: 1.031.21, I 2 =28%, p=0.005) and adjusted 1.10 (95% CI: 1.001.20, I 2 =34%, p=0.05)

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These findings underscore the importance of smoking cessation to improve outcomes after esophageal cancer diagnosis

How Tobacco Chewing Affects Chronic Pain Inflammatory Response Chewing tobacco stimulates an inflammatory response throughout the body