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While ROS generation can help resolve inflammation by creating a hypoxic environment through oxygen depletion to activate anti-inflammatory pathways (Campbell et al., 2014), excessive and prolonged oxidative stress marked by an imbalance between ROS production and antioxidant defense can result in apoptosis and tissue damage (Rezaie et al., 2007)

Dre would do something similar for his debut album The Chronic.) Another famous example of artists incorporating rolling paper logos into their projects were Cheech & Chong