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[5] Notably, normal feedback mechanisms remain intact: elevated IGF-1 and GH can signal the hypothalamus and pituitary to modulate further hormone release, which may reduce the risk of extreme hormone levels

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It is estimated that global case numbers for each site of OA will increase by 48.6% to 95.1% between 2020 and 2050 [8], underscoring the pressing need for better therapies [9,10]