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However, the arrival of cigarette-making machines made the production of cigarettes much cheaper and faster, and soon they became the preferred method of smoking for millions of people all over the world

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Therefore, the limited brand to brand variation in nitrate levels (excluding American Spirit cigarettes) of the cigarettes used in this experiment was not sufficient to confirm the relationship between nitrate and GP due to variations in other design characteristics that could not be controlled for (i.e., additive composition, paper porosity, filter density, etc.)