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cidofovir a) Encapsulation et libration du Cidofovir (CDV) L'adsorption de Cidofovir (L (S)-l-(3-hydroxy- 2-phosphonyl-methoxypropyl)cytosine, CDV, Moravek) a t tudie dans les nanoparticules du MIL-88A, MIL-89, MIL-100 et MIL-101, en utilisant le CDV marqu au 14 C (14C-CDV )a) Encapsulation and release of Cidofovir (CDV) The adsorption of Cidofovir (L (S) -1- (3-hydroxy-2-phosphonyl-methoxypropyl) cytosine, CDV, Moravek) was studied in the nanoparticles of MIL-88A , MIL-89, MIL-100 and MIL-101, using the TAC 14 C (14 C-VCT) Les expriences sont faites en triple, en suspendant 2 mg du matriau pralablement dshydrat (150C/nuit pour MIL_100 et pour le reste 100C/nuit) dans 1 mL d'une solution aqueuse de 400g/ml CDV (50l de 14C-CDV+ 3ml de CDV) temprature ambiante sous agitation pendant 16h.The experiments are carried out in triplicate, by suspending 2 mg of the previously dehydrated material (150 C / night for MIL_100 and for the remainder 100 C / night) in 1 mL of an aqueous solution of 400 g / ml CDV (50 l of 14 C -CDV + 3ml of CDV) at room temperature with stirring for 16h
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