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This can include: Autoimmune disorders (including systemic lupus erythematosus) Bleeding disorders Cancer of the mouth Infections such as hand-foot-mouth disease Weakened immune system -- for example, if you have AIDS or are taking medicine to suppress your immune system after a transplant Drugs that may cause mouth sores include aspirin, beta-blockers, chemotherapy medicines, penicillamine, sulfa drugs, and phenytoin