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Research suggests it may influence angiogenesis, nitric oxide signalling, collagen pathways, and repair-cell activity, but these mechanisms have not been shown to produce proven healing benefits in humans

Toxicol Sci 2007;99:628-36

20.5.3 Pathogenesis Caf au lait macules in children are common dermatologic findings that can arise in a variety of disease conditions, such as neurofibromatosis type 1 and certain types of hereditary syndromes , such as McCune-Albright, Cowden, LEOPARD, and Bannayan-Riley-Ruvalcaba syndromes [29]